Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ.

ABSTRACT:

Background

Microglia are the resident immune cells found in our brain. They have a critical role in brain maintenance. Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Aβ. Through phagocytosis of Aβ, microglia prevent the accumulation of Aβ plaque in the brain. However, in Alzheimer's disease (AD) patients, chronic exposure to Aβ makes microglia to become exhausted, which reduces their phagocytic activity against Aβ. Since microglia play an important role in Aβ clearance, enhancing microglial phagocytic activity against Aβ is a promising target for AD treatment. Therefore, there is a great need for therapeutic candidate that enhances microglial Aβ clearance while inhibiting microglia's pathogenic properties.

Methods

SUBMITTER: Jo KW 

PROVIDER: S-EPMC9585741 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature