Development and clinical validation of CT-based regional modified Centiloid method for amyloid PET.

ABSTRACT:

Background

The standard Centiloid (CL) method was proposed to harmonize and quantify global ¹⁸F-labeled amyloid beta (Aβ) PET ligands using MRI as an anatomical reference. However, there is need for harmonizing and quantifying regional Aβ uptakes between ligands using CT as an anatomical reference. In the present study, we developed and validated a CT-based regional direct comparison of ¹⁸F-florbetaben (FBB) and ¹⁸F-flutemetamol (FMM) Centiloid (rdcCL).

Methods

For development of MRI-based or CT-based rdcCLs, the cohort consisted of 63 subjects (20 young controls (YC) and 18 old controls (OC), and 25 participants with Alzheimer's disease dementia (ADD)). We performed a direct comparison of the FMM-FBB rdcCL method using MRI and CT images to d

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC9585745 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature