Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid.

ABSTRACT:

Background

The availability of new biological platform organisms to get access to innovative products and processes is fundamental for the progress in biotechnology and bioeconomy. The amoeba Dictyostelium discoideum represents a novel host system that has recently been employed for both the discovery of new natural products and as a cell factory for the production of bioactive compounds such as phytochemicals. However, an essential parameter to evaluate the potential of a new host system is the demonstration of its scalability to allow industrial applicability. Here, we aimed to develop a bioprocess for the production of olivetolic acid, the main precursor of cannabinoids synthesized by a recently engineered D. discoideum strain.

Results

In this study, a sophisticated appro

SUBMITTER: Kufs JE 

PROVIDER: S-EPMC9585784 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature