Repeatability assessment of sodium (²³Na) MRI at 7.0 T in healthy human calf muscle and preliminary results on tissue sodium concentrations in subjects with Addison's disease.

ABSTRACT:

Objectives

To determine the relaxation times of the sodium nucleus, and to investigate the repeatability of quantitative, in vivo TSC measurements using sodium magnetic resonance imaging (²³Na-MRI) in human skeletal muscle and explore the discriminatory value of the method by comparing TSCs between healthy subjects and patients with Addison's disease.

Materials and methods

In this prospective study, ten healthy subjects and five patients with Addison's disease were involved. ²³Na-MRI data sets were acquired using a density-adapted, three-dimensional radial projection reconstruction pulse sequence (DA-3DPR) with a modification for the relaxation times measurements. Differences in TSC between muscle groups and between healthy participants were analysed us

SUBMITTER: Zaric O 

PROVIDER: S-EPMC9585786 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature