Orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control.

ABSTRACT:

Background

Lipid homeostasis is an evolutionarily conserved process that is crucial for energy production, storage and consumption. Drosophila larvae feed continuously to achieve the roughly 200-fold increase in size and accumulate sufficient reserves to provide all energy and nutrients necessary for the development of the adult fly. The mechanisms controlling this metabolic program are poorly understood.

Results

Herein we identified a highly conserved gene, orsai (osi), as a key player in lipid metabolism in Drosophila. Lack of osi function in the larval fat body, the regulatory hub of lipid homeostasis, reduces lipid reserves and energy output, evidenced by decreased ATP production and increased ROS levels. Metabolic defects due to reduced Orsai (Osi) in time trigger defec

SUBMITTER: Fernandez-Acosta M 

PROVIDER: S-EPMC9585818 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature