Tumour stroma ratio is a potential predictor for 5-year disease-free survival in breast cancer

ABSTRACT:

Background

The tumour–stroma ratio (TSR) is identified as a promising prognostic parameter for breast cancer, but the cutoff TSR value is mostly assessed by visual assessment, which lacks objective measurement. The aims of this study were to optimize the cutoff TSR value, and evaluate its prognosis value in patients with breast cancer both as continuous and categorical variables.

Methods

Major clinicopathological and follow-up data were collected for a series of patients with breast cancer. Tissue microarray images stained with cytokeratin immunohistochemistry were evaluated by automated quantitative image analysis algorithms to assess TSR. The potential cutoff point for TSR was optimized using maximally selected rank statistics. The association between TSR and 5-year dis

SUBMITTER: Yan D 

PROVIDER: S-EPMC9585868 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature