Latent brain state dynamics and cognitive flexibility in older adults.
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ABSTRACT:
SUBMITTER: Lee B
PROVIDER: S-EPMC9585912 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Latent brain state dynamics and cognitive flexibility in older adults.
Lee Byeongwook B Cai Weidong W Young Christina B CB Yuan Rui R Ryman Sephira S Kim Jeehyun J Santini Veronica V Henderson Victor W VW Poston Kathleen L KL Menon Vinod V
Progress in neurobiology 20211007
Cognitive impairment in older adults is a rapidly growing public health concern as the elderly population dramatically grows worldwide. While it is generally assumed that cognitive deficits in older adults are associated with reduced brain flexibility, quantitative evidence has been lacking. Here, we investigate brain flexibility in healthy older adults (ages 60-85) using a novel Bayesian switching dynamical system algorithm and ultrafast temporal resolution (TR = 490 ms) whole-brain fMRI data d ...[more]
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