From COPD to Lung Cancer: Mechanisms Linking, Diagnosis, Treatment, and Prognosis.

ABSTRACT: Many studies have proved that the pathogenesis of the chronic obstructive pulmonary disease (COPD) and lung cancer is related, and may cause and affect each other to a certain extent. In fact, the change of chronic airway obstruction will continue to have an impact on the screening, treatment, and prognosis of lung cancer.In this comprehensive review, we outlined the links and heterogeneity between COPD and lung cancer and finds that factors such as gene expression and genetic susceptibility, epigenetics, smoking, epithelial mesenchymal transformation (EMT), chronic inflammation, and oxidative stress injury may all play a role in the process. Although the relationship between these two diseases have been largely determined, the methods to prevent lung cancer in COPD patients are still limi

SUBMITTER: Qi C 

PROVIDER: S-EPMC9586171 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature