Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates.

ABSTRACT: Leptospirosis is a neglected disease of man and animals that affects nearly half a million people annually and causes considerable economic losses. Current human vaccines are inactivated whole-cell preparations (bacterins) of Leptospira spp. that provide strong homologous protection yet fail to induce a cross-protective immune response. Yearly boosters are required, and serious side-effects are frequently reported so the vaccine is licensed for use in humans in only a handful of countries. Novel universal vaccines require identification of conserved surface-exposed epitopes of leptospiral antigens. Outer membrane β-barrel proteins (βb-OMPs) meet these requirements and have been successfully used as vaccines for other diseases. We report the evaluation of 22 constructs containing pro

SUBMITTER: Maia MAC 

PROVIDER: S-EPMC9586249 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature