Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent.

ABSTRACT: Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter

SUBMITTER: Jin Z 

PROVIDER: S-EPMC9586266 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature