Prenatal exposure to maternal social disadvantage and psychosocial stress and neonatal white matter connectivity at birth.

ABSTRACT: Early life adversity (social disadvantage and psychosocial stressors) is associated with altered microstructure in fronto-limbic pathways important for socioemotional development. Understanding when these associations begin to emerge may inform the timing and design of preventative interventions. In this longitudinal study, 399 mothers were oversampled for low income and completed social background measures during pregnancy. Measures were analyzed with structural equation analysis resulting in two latent factors: social disadvantage (education, insurance status, income-to-needs ratio [INR], neighborhood deprivation, and nutrition) and psychosocial stress (depression, stress, life events, and racial discrimination). At birth, 289 healthy term-born neonates underwent a diffusion MRI (dMRI) s

SUBMITTER: Lean RE 

PROVIDER: S-EPMC9586270 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature