Microbiome composition modulates secondary metabolism in a multispecies bacterial community.

ABSTRACT: Bacterial secondary metabolites are a major source of antibiotics and other bioactive compounds. In microbial communities, these molecules can mediate interspecies interactions and responses to environmental change. Despite the importance of secondary metabolites in human health and microbial ecology, little is known about their roles and regulation in the context of multispecies communities. In a simplified model of the rhizosphere composed of Bacillus cereus, Flavobacterium johnsoniae, and Pseudomonas koreensis, we show that the dynamics of secondary metabolism depend on community species composition and interspecies interactions. Comparative metatranscriptomics and metametabolomics reveal that the abundance of transcripts of biosynthetic gene clusters (BGCs) and met

SUBMITTER: Chevrette MG 

PROVIDER: S-EPMC9586298 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature