Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1.

ABSTRACT: An overarching goal of aging and age-related neurodegenerative disease research is to discover effective therapeutic strategies applicable to a broad spectrum of neurodegenerative diseases. Little is known about the extent to which targetable pathogenic mechanisms are shared among these seemingly diverse diseases. Translational control is critical for maintaining proteostasis during aging. Gaining control of the translation machinery is also crucial in the battle between viruses and their hosts. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing COVID-19 pandemic. Here, we show that overexpression of SARS-CoV-2-encoded nonstructural protein 1 (Nsp1) robustly rescued neuromuscular degeneration and behavioral phenotypes in Drosophila mod

SUBMITTER: Wang X 

PROVIDER: S-EPMC9586304 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature