Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.

ABSTRACT:

Purpose

It has been reported that bone is the primary organ for manganese (Mn) accumulation, but the association between manganese and bone loss remains debatable. Therefore, this study aimed to evaluate the relationship between blood manganese and bone mineral density/bone mineral content (BMD/BMC) by using a representative sample from the National Health and Nutrition Examination Survey (NHANES).

Methods

A total of 9732 subjects over the age of 18 with available data were enrolled in this study. The relationship between blood manganese and BMD/BMC of the total body, spine and femoral regions was evaluated using multivariate linear regression models. Subgroup analyses were also performed.

Results

We observed a negative association between blood manganese and BMD/BMC

SUBMITTER: Wang C 

PROVIDER: S-EPMC9586363 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature