Sex as a determinant of disease severity and clinical outcome in febrile children under five presenting to a regional referral hospital in Uganda.

ABSTRACT: Sex and gender are well-established determinants of health in adult and adolescent populations in low resource settings. There are limited data on sex as a determinant of host response to disease and clinical outcome in febrile children in sub-Saharan Africa, where the risk of infection-related mortality is greatest. We examined sex differences and gender biases in health-seeking behavior, clinical care, biological response to infection, or outcome in a prospective observational cohort of febrile children under 5 years of age presenting to a regional referral hospital in Jinja, Uganda. Main outcomes (stratified by sex) were disease severity at presentation measured by clinical and biological parameters, clinical management (e.g., time to see a physician, treatment by diagnosis), and diseas

SUBMITTER: McDonald CR 

PROVIDER: S-EPMC9586386 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature