A Mendelian randomization study investigating the causal role of inflammation on Parkinson's disease.

ABSTRACT: There is increasing evidence for inflammation as a determinant in the pathogenesis of Parkinson's disease, but its role in parkinsonian neurodegeneration remains elusive. It is not clear whether inflammatory cascades are causes or consequences of dopamine neuron death. In the present study, we aim to perform an in-depth statistical investigation of the causal relationship between inflammation and Parkinson's disease using a two-sample Mendelian randomization design. Genetic instruments were selected using summary-level data from the largest genome-wide association studies to date (sample size ranging from 13 955 to 204 402 individuals) conducted on a European population for the following inflammation biomarkers: C-reactive protein, interleukin-6, interleukin 1 receptor antagonist and tumou

SUBMITTER: Bottigliengo D 

PROVIDER: S-EPMC9586538 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature