Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: a 7 T MRI study.

ABSTRACT: Cortical lesions constitute a key manifestation of multiple sclerosis and contribute to clinical disability and cognitive impairment. Yet it is unknown whether local cortical lesions and cortical lesion subtypes contribute to domain-specific impairments attributable to the function of the lesioned cortex. In this cross-sectional study, we assessed how cortical lesions in the primary sensorimotor hand area relate to corticomotor physiology and sensorimotor function of the contralateral hand. Fifty relapse-free patients with relapsing-remitting or secondary-progressive multiple sclerosis and 28 healthy age- and sex-matched participants underwent whole-brain 7 T MRI to map cortical lesions. Brain scans were also used to estimate normalized brain volume, pericentral cortical thickness, white m

SUBMITTER: Madsen MAJ 

PROVIDER: S-EPMC9586550 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature