The ellipse of insignificance, a refined fragility index for ascertaining robustness of results in dichotomous outcome trials.

ABSTRACT: There is increasing awareness throughout biomedical science that many results do not withstand the trials of repeat investigation. The growing abundance of medical literature has only increased the urgent need for tools to gauge the robustness and trustworthiness of published science. Dichotomous outcome designs are vital in randomized clinical trials, cohort studies, and observational data for ascertaining differences between experimental and control arms. It has however been shown with tools like the fragility index (FI) that many ostensibly impactful results fail to materialize when even small numbers of patients or subjects in either the control or experimental arms are recoded from event to non-event. Critics of this metric counter that there is no objective means to determine a meani

SUBMITTER: Grimes DR 

PROVIDER: S-EPMC9586556 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature