Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner.

ABSTRACT: At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1^SS4+) and neurexin-3 (Nrxn3^SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1^SS4+ and Nrxn3^SS4+ act by binding to secreted cerebellin-2 (Cbln2) that in turn activates postsynaptic GluD1 receptors. Whether neurexin-Cbln2-GluD1 signaling has additional functions besides regulating NMDA- and AMPA-receptors, and whether such signaling performs similar roles at other synapses, however, remains unknown. Here, we demonstrate using constitutive Cbln2 deletions in mice that at CA1→subiculum synapses, Cbln2 performs no additional developmental roles besides regulating AMPA- and NMDA-receptors. Moreover, low-level expression of f

SUBMITTER: Dai J 

PROVIDER: S-EPMC9586558 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature