Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis.

ABSTRACT: The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcriptional regulator plays a pivotal role in the pathogenesis of diverse A. baumannii clinical strains in multiple murine and G. mellonella invertebrate infection models. We identified OmpR-regulated genes using RNA sequencing and further validated two genes whose expression can be used as robust biomarker to quantify OmpR inhibition in A. baumannii. Moreover, the determination of the structure of the OmpR DNA binding domain of A. baumannii and the development of in vitro protein-DNA binding assays enabled the identification

SUBMITTER: Trebosc V 

PROVIDER: S-EPMC9586577 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature