Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth.

ABSTRACT: Maternal pregnancy fatty acid status is associated with child health. Epigenetic gestational age acceleration, referring to a discrepancy between chronological and epigenetic gestational age, may underlie these associations. Previous research suggests that analysing fatty acid patterns rather than individual fatty acids may overcome the caveat of missing synergistic or additive effects. Among 1226 mother-newborn pairs from the population-based Generation R Study, we examined the associations of three maternal plasma mid-pregnancy fatty acid patterns, identified by principal component analysis, with offspring epigenetic gestational age acceleration. This was estimated from cord blood DNA methylation data using the method developed by Bohlin. As a secondary analysis, we used the method devel

SUBMITTER: Monasso GS 

PROVIDER: S-EPMC9586633 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature