Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes.

ABSTRACT: Melanosomes are melanin-containing organelles in melanocytes, and they are responsible for skin and hair pigmentation in mammals. The intracellular distribution of melanosomes is mainly determined by the balance between their anterograde transport on actin filaments and retrograde transport on microtubules. Although we have shown previously that melanoregulin and Rab36 serve as cargo receptors on melanosomes for retrograde transport, their knockdown does not completely inhibit retrograde melanosome transport, suggesting the existence of an additional cargo receptor(s) in melanocytes. In this study, we investigated the possible involvement of an atypical large Rab, Rab44, which also contains EF-hand domains and a coiled-coil domain, in retrograde melanosome transport in mouse melanocytes (R

SUBMITTER: Maruta Y 

PROVIDER: S-EPMC9586991 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature