Pharmacological effects of caffeine on ventilation in adult zebrafish under free-swimming conditions.

ABSTRACT: The zebrafish is widely used as a model in biological studies. In particular, the heart rate and cortisol levels of zebrafish are commonly measured to elucidate the pharmacological effects of chemical substances. Meanwhile, although ventilation is also an important physiological index reflecting emotion-like states, few studies have evaluated the effects of chemicals on ventilation in adult zebrafish. In this study, we assessed whether it is possible to evaluate the pharmacological effects elicited by caffeine in adult zebrafish under free-swimming conditions. We measured the ventilation in adult zebrafish exposed to multiple concentrations of caffeine under restraint and free-swimming conditions and evaluated the pharmacological effects of caffeine using linear mixed model analysis. In ad

SUBMITTER: Harada Y 

PROVIDER: S-EPMC9587047 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature