Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments.

ABSTRACT: Hypoxia is a condition where tissue oxygen levels fall below normal levels. In locally induced hypoxia due to blood vessel blockage, oxygen delivery becomes compromised. The site where blood flow is diminished the most forms a zero-oxygen core, and different oxygenation zones form around this core with varying oxygen concentrations. Naturally, these differing oxygen microenvironments drive cells to respond according to their oxygenation status. To study these cellular processes in laboratory settings, the cellular gas microenvironments should be controlled rapidly and precisely. In this study, we propose an organ-on-a-chip device that provides control over the oxygen environments in three separate compartments as well as the possibility of rapidly changing the corresponding oxygen concentr

SUBMITTER: Tornberg K 

PROVIDER: S-EPMC9587069 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature