Efficacy and safety of adjunctive therapy to lamotrigine, lithium, or valproate monotherapy in bipolar depression: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

The efficacy and safety of adjunctive therapy are unclear in bipolar depression. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of second-generation antipsychotic, lamotrigine, lithium, or valproate therapy used in adjunction with lamotrigine, lithium, or valproate monotherapy in bipolar depression. A literature search of major electronic databases was conducted in February 2021, and all articles published until then were eligible. Two researchers independently screened relevant publications, extracted data, and evaluated methodological quality according to the Cochrane criteria.

Results

Five studies met the inclusion criteria. The meta-analysis revealed significant differences in the following outcomes: (i) remission rat

SUBMITTER: Maruki T 

PROVIDER: S-EPMC9587199 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature