Incidence and predictors of toxicity in the management of vulvar squamous cell carcinoma treated with radiation therapy

ABSTRACT: Highlights • Definitive or adjuvant RT with or without chemotherapy for vulvar cancer was associated significant morbidity.• 23.8 % of patients developed acute grade ≥ 3 skin toxicity.• 26.2 % of patients developed late grade ≥ 3 skin toxicity.• Higher BMI was associated with increased incidence of late grade ≥ 3 skin toxicity.• Vaginal pain, skin fibrosis, and persistent requirement of opiates were common ≥ 90 days post-RT.

Purpose/Objective

Given the rarity of vulvar cancer, data on the incidence of acute and late severe toxicity and patients’ symptom burden from radiotherapy (RT) are lacking.

Materials/Methods

This multi-center, single-institution study included patients with vulvar squamous cell carcinoma treated with curative intent RT between 2009 and 2020. Treatmen

SUBMITTER: McCall N 

PROVIDER: S-EPMC9587278 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature