Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles.

ABSTRACT: Chemically coated micro/nanoparticles are often used in medicine to enhance drug delivery and increase drug up-take into specific areas of the body. Using a recently discovered spontaneous symmetry breaking propulsion mechanism, we demonstrate that chemically coated microparticles can swim through mucus solution under precise navigation and that certain functionalizations can dynamically change propulsion behavior. For this investigation biotin, Bitotin-PEG3-amine, and biotin chitosan were chemically functionalized onto the surfaces of magnetic microparticles using an avidin-biotin complex. These chemicals were chosen because they are used prolifically in drug delivery applications, with PEG and chitosan having well known mucoadhesive effects. Coated microparticles were then suspended in m

SUBMITTER: Rogowski LW 

PROVIDER: S-EPMC9587300 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature