Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons.

ABSTRACT: A model was previously proposed that DA neurons provide SHH ligand to striatal interneurons, which in turn support the survival of DA neurons through the release of trophic factors such as Glial cell-derived neurotrophic factor (GDNF). However, some key clinical observations do not support this proposed model, and a recent independent study shows that striatal cholinergic neuron survival does not rely on intact DA neuron projections. To resolve this discrepancy, we generated several independent mouse lines to examine the exact role of DA neuron-derived Shh signaling in the maintenance of the basal ganglia circuit and to identify the Shh-producing cells in the adult brain. Our data suggest that the deletion of Shh in DA neurons does not affect DA neuron survival or loco

SUBMITTER: Turcato FC 

PROVIDER: S-EPMC9587326 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature