Influence of age as a continuous variable on the prognosis of patients with pT1-2N1 breast cancer.

ABSTRACT: To assess the influence of age as a continuous variable on the prognosis of pT1-2N1 breast cancer and examine its decision-making value for postmastectomy radiotherapy (PMRT). We retrospectively evaluated 5438 patients with pT1-2N1 breast cancer after mastectomy in 11 hospitals. A multivariable Cox proportional hazards regression model with penalized splines was used to examine the relationship between age and oncologic outcomes. The median follow-up was 67.0 months. After adjustments for confounding characteristics, nonsignificant downward trend in locoregional recurrence (LRR) risk was observed with increasing age (P-non-linear association = 0.640; P-linear association = 0.078). A significant non-linear association was found between age and disease-free survival (DFS) and overall surviva

SUBMITTER: Zhao XR 

PROVIDER: S-EPMC9587343 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature