Liposomes trigger bone marrow niche macrophage "foam" cell formation and affect hematopoiesis in mice.

ABSTRACT: Liposomes are the most widely used nanocarrier platform for the delivery of therapeutic and diagnostic agents, and a number of liposomes have been approved for use in clinical practice. After systemic administration, most liposomes are cleared by macrophages in the mononuclear phagocyte system, such as the liver and bone marrow (BM). However, the majority of studies have focused on investigating the therapeutic results of liposomal drugs, and too few studies have evaluated the potential side effects of empty nanocarriers on the functions of macrophages in the mononuclear phagocyte system. Here, we evaluate the potential effects of empty liposomes on the functions of BM niche macrophages. Following liposome administration, we observed lipid droplet (LD) accumulation in cultured primary macr

SUBMITTER: Li Y 

PROVIDER: S-EPMC9587404 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature