Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema.

ABSTRACT:

Purpose

Diabetic macular edema (DME) is the leading cause of vision loss and blindness among working-age adults. Although current intravitreal anti-vascular endothelial growth factor (VEGF) therapies improve vision for many patients with DME, approximately half do not achieve the visual acuity required to drive. We therefore sought additional approaches to resolve edema and improve vision for these patients.

Methods

We explored direct agonists of Tie2, a receptor known to stabilize vasculature and prevent leakage. We identified a multivalent PEG-Fab conjugate, Tie2.1-hexamer, that oligomerizes Tie2 and drives receptor activation and characterized its activities in vitro and in vivo.

Results

Tie2.1-hexamer normalized and stabilized intercellular junctions of stressed e

SUBMITTER: Agard NJ 

PROVIDER: S-EPMC9587485 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature