Repurposing Antihypertensive Drugs for the Prevention of Glaucoma: A Mendelian Randomization Study.

ABSTRACT:

Purpose

Several antihypertensive drugs have been used for the treatment of glaucoma. However, the effect of hypertension and antihypertensive drugs on glaucoma is still unclear.

Methods

Leveraging large-scale genome-wide association study summary statistics for glaucoma (Ncase = 4737, Ncontrol = 458,196), blood pressure (BP) (N = 422,771), and intraocular pressure (IOP) (N = 31,269), the genetic correlation and causal relationship of genetically assessed IOP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and 12 types of antihypertensive drugs with glaucoma were evaluated using linkage disequilibrium score (LDSC) regression, univariate mendelian randomization (MR), and multivariable MR.

Results

LDSC results showed a suggestive association of glaucoma w

SUBMITTER: Liu J 

PROVIDER: S-EPMC9587511 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature