Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model.

ABSTRACT:

Background

Recombinant tissue plasminogen activator (rtPA) has a short half-life, and additional hemorrhagic transformation (HT) can occur when treatment is delayed. Here, we report the design and thrombolytic performance of 3 [Formula: see text]m discoidal polymeric particles loaded with rtPA and superparamagnetic iron oxide nanoparticles (SPIONs), referred to as rmDPPs, to address the HT issues of rtPA.

Methods

The rmDPPs consisted of a biodegradable polymeric matrix, rtPA, and SPIONs and were synthesized via a top-down fabrication.

Results

The rmDPPs could be concentrated at the target site with magnetic attraction, and then the rtPA could be released under acoustic stimulus. Therefore, we named that the particles had magnetoacoustic properties. For the in vitro bl

SUBMITTER: Choi W 

PROVIDER: S-EPMC9587564 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature