Jatrorrhizine alleviates ulcerative colitis via regulating gut microbiota and NOS2 expression.

ABSTRACT:

Background

The natural protoberberine jatrorrhizine (JA) is reported to have several medicinal properties and a significant effect on the gut microbiota of mice. The regulation of gut microbiota is generally known to play an important role in the intestinal mucosal immune response to ulcerative colitis (UC). However, whether JA can be used in the treatment of UC is still unclear. Our study aimed to investigate the underlying therapeutic effects and mechanisms of JA in treating colitis.

Results

Compared with the DSS-induced colitis model group, the JA + DSS treated group had more significant improvements in weight loss, disease activity index score, colon length shortening, and pathological inflammation. 16s rRNA sequencing analysis showed that JA treatment protected colitis

SUBMITTER: Zhang JL 

PROVIDER: S-EPMC9587631 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature