Outcomes of protocolised analgesia and sedation in a neurocritical care unit.

ABSTRACT:

Objectives

Providing analgesia and sedation while allowing for neurological assessment is important in the neurocritical care unit (NCCU), yet data are limited about the effects of protocolised analgesia and sedation. We developed an analgesia-based sedation protocol and evaluated its effect on medication utilisation and costs in the NCCU.

Methods

We conducted a retrospective cohort study of patients who are mechanically ventilated and admitted to a 12-bed NCCU over four years. To compare outcomes, we used gamma and negative binomial regression models, and interrupted time-series sensitivity analyses.

Results

The study cohort consisted of 1197 patients: 576 pre-protocol and 621 post-protocol. The protocol resulted in an increase in fentanyl use [incidence rate ratio (

SUBMITTER: Mahmoud L 

PROVIDER: S-EPMC9587753 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature