Pattern of lymph node metastases in gastric cancer: a side-study of the multicenter LOGICA-trial.

ABSTRACT:

Background

The relation between gastric cancer characteristics and lymph node (LN) metastatic patterns is not fully clear, especially following neoadjuvant chemotherapy (NAC). This study analyzed nodal metastatic patterns.

Methods

Individual LN stations were analyzed for all patients from the LOGICA-trial, a Dutch multicenter randomized trial comparing laparoscopic versus open D2-gastrectomy for gastric cancer. The pattern of metastases per LN station was related to tumor location, cT-stage, Lauren classification and NAC.

Results

Between 2015-2018, 212 patients underwent D2-gastrectomy, of whom 158 (75%) received NAC. LN metastases were present in 120 patients (57%). Proximal tumors metastasized predominantly to proximal LN stations (no. 1, 2, 7 and 9; p < 0.05), and

SUBMITTER: de Jongh C 

PROVIDER: S-EPMC9587950 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature