Slow-oscillatory tACS does not modulate human motor cortical response to repeated plasticity paradigms.

ABSTRACT: Previous history of activity and learning modulates synaptic plasticity and can lead to saturation of synaptic connections. According to the synaptic homeostasis hypothesis, neural oscillations during slow-wave sleep play an important role in restoring plasticity within a functional range. However, it is not known whether slow-wave oscillations-without the concomitant requirement of sleep-play a causal role in human synaptic homeostasis. Here, we aimed to answer this question using transcranial alternating current stimulation (tACS) to induce slow-oscillatory activity in awake human participants. tACS was interleaved between two plasticity-inducing interventions: motor learning, and paired associative stimulation (PAS). The hypothesis tested was that slow-oscillatory tACS would prevent hom

SUBMITTER: Bradley C 

PROVIDER: S-EPMC9587974 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature