RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.

ABSTRACT: CD271 (also referred to as nerve growth factor receptor or p75^NTR) is expressed on cancer stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation. Because elevated expression of CD271 increases cancer malignancy and correlates with poor prognosis, CD271 could be a promising therapeutic target; however, little is known about the induction of CD271 expression and especially its promoter activity. In this study, we screened transcription factors and found that RELA (p65), a subunit of nuclear factor kappaB (NF-κB), is critical for CD271 transcription in cancer cells. Specifically, we found that RELA promoted CD271 transcription in squamous cell carcinoma cell lines but not in normal epithelium and neuroblastoma cell lines. Within the CD271 promoter sequence, regi

SUBMITTER: Nakazato A 

PROVIDER: S-EPMC9588052 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature