Comparison of [¹⁸F]-FDOPA PET and [¹²³I]-FP-CIT SPECT acquired in clinical practice for assessing nigrostriatal degeneration in patients with a clinically uncertain parkinsonian syndrome.

ABSTRACT:

Purpose

Two commonly used imaging techniques to aid in the diagnosis of neurodegenerative parkinsonian syndromes are dopamine transporter (DAT) imaging with [¹²³I]-FP-CIT single-photon emission computed tomography (DAT-SPECT) and positron emission tomography with [¹⁸F]-FDOPA (FDOPA-PET). This paper provides a unique series of parkinsonian patients who received both FDOPA-PET and DAT-SPECT in routine clinical practice and compares the reported results to assess potential differences between these two imaging techniques.

Methods

We present 11 patients with a clinically uncertain parkinsonian syndrome (CUPS), who received both FDOPA-PET and DAT-SPECT. All patients received an FDOPA-PET scan and DAT-SPECT as part of routine clinical care.

Results

The

SUBMITTER: Wallert E 

PROVIDER: S-EPMC9588108 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature