Integrated assessment of the clinical and biological value of ferroptosis-related genes in multiple myeloma.

ABSTRACT:

Background

Ferroptosis is an iron-dependent mode of cell death that could be induced by erastin and exert antitumor effects. However, the clinical and biological roles of ferroptosis-related gene (FRG) signature and the therapeutic value of erastin in multiple myeloma (MM) remained unknown.

Methods

Clinical and gene expression data of MM subjects were extracted from the Gene Expression Omnibus (GEO) public database. Univariable cox analysis was applied to determine FRGs related to survival and the least absolute shrinkage and selection operator (LASSO) regression analysis was used to develop a prognostic model. Prediction accuracy of the model was estimated by receiver operating characteristic (ROC) curves. Functional pathway enrichments and infiltrating immune status were a

SUBMITTER: Fu B 

PROVIDER: S-EPMC9588243 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature