Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis.

ABSTRACT:

Objectives

This study aimed to determine the therapeutic effect of equol (EQ) on osteoporotic osteoarthritis (OP OA).

Materials and methods

Thirty-six 12-week-old female Sprague-Dawley rats were randomly divided into sham group, OP OA group, and EQ group (n=12). OP OA was induced by anterior cruciate ligament transection (ACLT) combined with ovariectomy (OVX). EQ was orally administrated (10 μg/g/day) after the operation for 12 weeks. The efficacy was evaluated by gross pathology and histopathologic evaluation. The underlying mechanism was investigated by immunohistochemical analysis, micro-computed tomography (micro-CT) scanning, and tartrate-resistant acid phosphatase (TRAP) staining.

Results

EQ effectively retarded cartilage degeneration, decreased the levels of ma

SUBMITTER: Ping SH 

PROVIDER: S-EPMC9588321 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature