A Three-Year Prospective Study Assessing the Application of Chromosomal Microarray Analysis in 576 High-Risk Pregnant Women.

ABSTRACT:

Background

The use of chromosomal microarray analysis (CMA) in prenatal diagnosis of chromosomal and genetic diseases has resulted in a significant improvement in the diagnosis of genetically caused congenital malformations, neurodevelopmental disorders, and congenital anomalies, with a high diagnostic yield in selected prenatal cases.

Objective

The objective of this study was to evaluate the application of CMA in the prenatal diagnosis of high-risk pregnant women.

Method

A total of 576 pregnancies were selected from May 2018 to October 2020 in our hospital, including amniotic fluid chromosome, karyotype analysis, and CMA detection. The study group was divided into two groups based on the indications for testing: group A has 88 patients at the age of 35 years or older

SUBMITTER: Jiang M 

PROVIDER: S-EPMC9588346 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature