Heterologous SARS-CoV-2 IgA neutralising antibody responses in convalescent plasma.

ABSTRACT:

Objectives

Following infection with SARS-CoV-2, virus-specific antibodies are generated, which can both neutralise virions and clear infection via Fc effector functions. The importance of IgG antibodies for protection and control of SARS-CoV-2 has been extensively reported. By comparison, other antibody isotypes including IgA have been poorly characterised.

Methods

Here, we characterised plasma IgA from 41 early convalescent COVID-19 subjects for neutralisation and Fc effector functions.

Results

Convalescent plasma IgA from > 60% of the cohort had the capacity to inhibit the interaction between wild-type RBD and ACE2. Furthermore, a third of the cohort induced stronger IgA-mediated ACE2 inhibition than matched IgG when tested at equivalent concentrations. Plasma IgA a

SUBMITTER: Davis SK 

PROVIDER: S-EPMC9588388 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature