Dataset Information

A Computational Neural Model for Mapping Degenerate Neural Architectures.

ABSTRACT: Degeneracy in biological systems refers to a many-to-one mapping between physical structures and their functional (including psychological) outcomes. Despite the ubiquity of the phenomenon, traditional analytical tools for modeling degeneracy in neuroscience are extremely limited. In this study, we generated synthetic datasets to describe three situations of degeneracy in fMRI data to demonstrate the limitations of the current univariate approach. We describe a novel computational approach for the analysis referred to as neural topographic factor analysis (NTFA). NTFA is designed to capture variations in neural activity across task conditions and participants. The advantage of this discovery-oriented approach is to reveal whether and how experimental trials and participants cluster into task conditions and participant groups. We applied NTFA on simulated data, revealing the appropriate degeneracy assumption in all three situations and demonstrating NTFA's utility in uncovering degeneracy. Lastly, we discussed the importance of testing degeneracy in fMRI data and the implications of applying NTFA to do so.

SUBMITTER: Khan Z

PROVIDER: S-EPMC9588472 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

A Computational Neural Model for Mapping Degenerate Neural Architectures.

Khan Zulqarnain Z Wang Yiyu Y Sennesh Eli E Dy Jennifer J Ostadabbas Sarah S van de Meent Jan-Willem JW Hutchinson J Benjamin JB Satpute Ajay B AB

Neuroinformatics 20220329 4

Degeneracy in biological systems refers to a many-to-one mapping between physical structures and their functional (including psychological) outcomes. Despite the ubiquity of the phenomenon, traditional analytical tools for modeling degeneracy in neuroscience are extremely limited. In this study, we generated synthetic datasets to describe three situations of degeneracy in fMRI data to demonstrate the limitations of the current univariate approach. We describe a novel computational approach for t ...[more]

PMID: 35349109

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Dataset Information

A Computational Neural Model for Mapping Degenerate Neural Architectures.

Publications

A Computational Neural Model for Mapping Degenerate Neural Architectures.

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