Higher Soluble CD163 in Blood Is Associated With Significant Depression Symptoms in Men With HIV.

ABSTRACT:

Background

People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS).

Setting

Four sites in the United States.

Methods

A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression Scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6, CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the bioma

SUBMITTER: Anderson AM 

PROVIDER: S-EPMC9588493 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature