Structural brain features signaling trauma, PTSD, or resilience? A systematic exploration.

ABSTRACT:

Background

Studies have searched for neurobiological markers of trauma exposure, posttraumatic stress disorder (PTSD) diagnosis, and resilience to trauma to identify therapeutic targets for PTSD. Despite some promising results, findings are inconsistent.

Aims

The present study adopted a data-driven approach to systematically explore whether structural brain markers of trauma, PTSD, or resilience emerge when all are explored.

Materials & methods

Differences between clusters in the proportion of PTSD, healthy controls (HC), and trauma-exposed healthy controls (TEHC) served to indicate the presence of PTSD, trauma, and resilience markers, respectively. A total of 129 individuals, including 46 with PTSD, 49 TEHCs, and 34 HCs not exposed to trauma were scanned. Volumes, co

SUBMITTER: Zilcha-Mano S 

PROVIDER: S-EPMC9588504 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature