Temporal Patterns and Adoption of Germline and Somatic BRCA Testing in Ovarian Cancer.

ABSTRACT:

Objective

To describe the testing rate, patient characteristics, temporal trends, timing, and results of germline and somatic BRCA testing in patients with ovarian cancer using real-world data.

Methods

We included a cross-sectional subset of adult patients diagnosed with ovarian cancer between January 1, 2011, and November 30, 2018, who received frontline treatment and were followed for at least 1 year in a real-world database. The primary outcome was receipt of BRCA testing, classified by biosample source as germline (blood or saliva) or somatic (tissue). Lines of therapy (frontline, second line, third line) were derived based on dates of surgery and chemotherapy. Descriptive statistics were analyzed.

Results

Among 2,557 patients, 72.2% (n=1,846) had at least one doc

SUBMITTER: Huepenbecker SP 

PROVIDER: S-EPMC9588544 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature