Tendon progenitor cells as biological augmentation improve functional gait and reduce scar formation after rotator cuff repair.

ABSTRACT:

Background

High rates of structural failure are reported after rotator cuff repairs due to inability to recreate the native enthesis during healing. The development of biological augmentation methods that mitigate scar formation and regenerate the enthesis is still an unmet need. Since neonatal enthesis is capable of regeneration after injury, this study tested whether delivery of neonatal tendon progenitor cells (TPCs) into the adult injured environment can enhance functional and structural supraspinatus enthesis and tendon healing.

Methods

TPCs were isolated from Ai14 Rosa26-TdTomato mouse Achilles tendons and labeled using adenovirus-Cre. Fifty-two CB57BL/6J mice underwent detachment and acute repair of the supraspinatus tendon and received either a fibrin-only or TPC-fib

SUBMITTER: Vervaecke AJ 

PROVIDER: S-EPMC9588545 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature