A systematic review and meta-analysis of cytology and HPV-related biomarkers for anal cancer screening among different risk groups.

ABSTRACT: To inform optimal approaches for detecting anal precancers, we performed a systematic review and meta-analysis of the diagnostic accuracy of anal cancer screening tests in different populations with elevated risk for anal cancer. We conducted a literature search of studies evaluating tests for anal precancer and cancer (anal intraepithelial neoplasia grade 2 or worse, AIN2+) published between January 1, 1997 to September 30, 2021 in PubMed and Embase. Titles and abstracts were screened for inclusion and included articles underwent full-text review, data abstraction and quality assessment. We estimated the prevalence of AIN2+ and calculated summary estimates and 95% confidence intervals (CI) of test positivity, sensitivity and specificity and predictive values of various testing strategies,

SUBMITTER: Clarke MA 

PROVIDER: S-EPMC9588562 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature