Shank3 influences mammalian sleep development.

ABSTRACT: Sleep problems are prevalent in autism spectrum disorder (ASD), can be observed before diagnosis, and are associated with increased restricted and repetitive behaviors. Therefore, sleep abnormalities may be a core feature of the disorder, but the developmental trajectory remains unknown. Animal models provide a unique opportunity to understand sleep ontogenesis in ASD. Previously we showed that adult mice with a truncation in the high-confidence ASD gene Shank3 (Shank3^∆C ) recapitulate the clinical sleep phenotype. In this study we used longitudinal electro-encephalographic (EEG) recordings to define, for the first time, changes in sleep from weaning to young adulthood in an ASD mouse model. We show that Shank3^∆C male mice sleep less overall throughout their lifespan,

SUBMITTER: Medina E 

PROVIDER: S-EPMC9588578 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature